Article: The 2019 Coronavirus Pandemic (SARS) - Hüseyin NAZLIKUL, Mehmet Ali ELMACIOĞLU, and Fatma…
As part of a fictitious consideration of the potential effects of the 2019 coronavirus pandemic (SARS), it is hypothesized that neural therapy with local anesthetics could be able to mitigate the adverse effects associated with the pandemic and the post-SARS phase.
Abstract
The COVID-19 outbreak, caused by the SARS-CoV-2 virus, continues to pose a significant global public health problem, with no definitive, universally effective treatment yet established. Due to its effects on vascular and immune responses, COVID-19 can lead to various serious complications affecting multiple organ systems, including the lungs, the peripheral and central nervous systems, the cardiovascular system, the kidneys, and the eyes.
The most prominent clinical manifestations involve the respiratory system, characterized by alveolar damage resulting from microembolisms and a widespread inflammatory cytokine response. In critically ill patients, this inflammatory response can turn into a cytokine storm, potentially leading to life-threatening complications. This study explores an alternative therapeutic perspective in addressing the pathophysiology and clinical symptoms of COVID-19, hypothesizing the potential benefits of local anesthetics, particularly through their effects on the autonomic nervous system (ANS).
Beyond the acute phase, a significant number of patients now experience persistent symptoms and complications referred to as "post-COVID syndrome" or "long COVID." These include chronic fatigue, respiratory difficulties, neurological and cognitive disorders, and cardiovascular symptoms that can continue for months after the initial infection. Post-COVID syndrome has highlighted the need for new treatment strategies that not only address acute symptoms but also support long-term recovery. Recent research has renewed interest in the therapeutic use of local anesthetics such as procaine and lidocaine due to their potential effects on inflammation and their capacity to modulate the autonomic nervous system. Neural therapy, a treatment method involving local anesthetic injection, can offer a promising approach for both acute COVID-19 management and post-COVID recovery by targeting dysregulated autonomic and inflammatory responses.
Key Message
We hypothesize that systemic applications and therapeutic local anesthetic injections (neural therapy) can support recovery in both acute COVID-19 cases and post-COVID syndrome. Local anesthetics, by acting on the autonomic nervous system, can help regulate inflammation, improve organ perfusion, and modulate central nervous system effects. This may alleviate the acute inflammatory response during infection and offer a potential pathway for more comprehensive patient care by addressing the persistent symptoms associated with post-COVID-19 syndrome.
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DOI: 10.24966/PMRR-0177/100092